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Opioid painkillers including codeine can result in constipation and could make you really feel sick. They can also make you drowsy, so don’t take an opioid painkiller if you might want to drive or operate machinery.CYP3A4 inducers, for instance rifampicin, carbamazepine, phenytoin and St John's Wort may possibly induce the metabolism of oxycodone